What if your brain fog, fatigue, and hypersensitivity weren’t “just anxiety”—but signs of a much deeper immune malfunction?
In this episode, Dr. Pradeep Chopra co-hosts a rare and revealing conversation with Dr. Theoharis Theoharides, the scientist who first discovered that mast cells communicate with microglia in the brain. Together, they dive into groundbreaking research on neuroinflammation, autism, histamine, stress, and why brain fog may not be “all in your head”—but inflammation inside it.
From overlooked biomarkers to misunderstood triggers, this episode unpacks the science most doctors still don’t know… but patients desperately need
Takeaways:
What you didn’t know about the link between stress and mast cell activation in the brain.
A surprising breakdown of how mast cells could be fueling neuroinflammation and foggy thinking.
Why autism and MCAS might share more than we think—especially in early development.
The overlooked role of environmental stressors in triggering immune responses that affect cognition.
How one researcher’s journey into mast cells rewrote everything we thought we knew about inflammation.
00:00 Amazon's New Supplement Regulations
00:34 Introduction to the Bendy Bodies Podcast
02:15 Understanding Mast Cell Activation Disorders
09:03 Symptoms and Diagnosis of Mast Cell Activation
40:04 Exploring Histamine and Parathyroid Hormone
41:40 Measuring Mast Cell Mediators
47:23 Histamine Intolerance and Supplements
53:42 Treatment Approaches for Mast Cell Activation
Want more Dr. Theoharis Theoharides?
Website: https://www.drtheoharides.com/
Podcast Link: https://algonot.com/
Blogs: https://www.nova.edu/nim/neuroinflammation-research/index.html
LinkedIn: https://www.linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735
Want more Dr. Pradeep Chopra?
Website: https://www.painri.com/
Reference Episodes:
Episode 70: https://youtu.be/BoRyQh12X2c
Episode 71: https://youtu.be/yDT3JTzfiJk
Episode 72: https://youtu.be/CYhnKkVjIxM
Episode 73: https://youtu.be/2OxtZGNswfo
Episode 77: https://youtu.be/d9A1aJB5GRoEpisode 139: https://youtu.be/u1pxvAzXh7M
Want more Dr. Linda Bluestein, MD?
Website: https://www.hypermobilitymd.com/.
YouTube: youtube.com/@bendybodiespodcast
Instagram: https://www.instagram.com/hypermobilitymd/
Facebook: https://www.facebook.com/BendyBodiesPodcast
X: https://twitter.com/BluesteinLinda
LinkedIn: https://www.linkedin.com/in/hypermobilitymd/
Newsletter: https://hypermobilitymd.substack.com/
Shop my Amazon store https://www.amazon.com/shop/hypermobilitymd
Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them.
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YOUR bendy body is our highest priority!
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